David Morgan, PhD

Vice Dean for Research
Physiology
+1 415 476-7229

David Morgan, PhD, is a Professor in the Department of Physiology, with an active research laboratory on the Mission Bay campus. As Vice Dean for Research in the School of Medicine, he serves as the Dean’s primary liaison to the school’s discovery community and its diverse research programs. He oversees internal funding programs and provides support and guidance for research training programs. As a member of the Office of Research leadership team, he works with the team to develop general research strategies and provide guidance and support for the many faculty and trainees who pursue basic and translational research at UCSF. 

Publications: 

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.

Molecular cell

Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Safari M, Frankel AD, Morgan DO

Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.

Nature communications

Rosen LE, Klebba JE, Asfaha JB, Ghent CM, Campbell MG, Cheng Y, Morgan DO

Quantitative framework for ordered degradation of APC/C substrates.

BMC biology

Lu D, Girard JR, Li W, Mizrak A, Morgan DO

An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.

The Journal of biological chemistry

Girard JR, Tenthorey JL, Morgan DO

Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.

The Journal of cell biology

Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO

Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency.

Current biology : CB

Van Voorhis VA, Morgan DO

The D box meets its match.

Molecular cell

Morgan DO

Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.

Current biology : CB

Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP

Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes.

The Journal of biological chemistry

Schaefer JB, Morgan DO

Dynamics of Cdk1 substrate specificity during the cell cycle.

Molecular cell

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M

Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.

Science (New York, N.Y.)

Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO

Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.

Molecular cell

Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP

Mechanisms of ubiquitin transfer by the anaphase-promoting complex.

Journal of biology

Matyskiela ME, Rodrigo-Brenni MC, Morgan DO

The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.

Molecular biology of the cell

Tully GH, Nishihama R, Pringle JR, Morgan DO

Cyclin-specific control of ribosomal DNA segregation.

Molecular and cellular biology

Sullivan M, Holt L, Morgan DO

Positive feedback sharpens the anaphase switch.

Nature

Holt LJ, Krutchinsky AN, Morgan DO

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.

Proceedings of the National Academy of Sciences of the United States of America

Blethrow JD, Glavy JS, Morgan DO, Shokat KM

A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.

Chemistry & biology

Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM

Finishing mitosis, one step at a time.

Nature reviews. Molecular cell biology

Sullivan M, Morgan DO

Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.

Molecular biology of the cell

Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR

An architectural map of the anaphase-promoting complex.

Genes & development

Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP

The APC subunit Doc1 promotes recognition of the substrate destruction box.

Current biology : CB

Carroll CW, Enquist-Newman M, Morgan DO

Enzymology of the anaphase-promoting complex.

Methods in enzymology

Carroll CW, Morgan DO

Oscillation sensation.

Nature

Morgan DO, Roberts JM