David Erle, MD

PROF IN RES-HCOMP
Professor of Medicine; Director
CoLabs
+1 415 514-4370

Dr. Erle received an A.B. degree (Biochemistry) from Harvard College in 1980 and an M.D. degree from UCSF in 1984. He was trained in internal medicine and in pulmonary disease at UCSF. As a CVRI research fellow training at the UCSF Lung Biology Center, he studied leukocyte integrins with Robert Pytela and Dean Sheppard. He joined the Lung Biology Center faculty in 1990. His academic activities include laboratory research and clinical teaching. He founded the UCSF Functional Genomics Core Facility. He is a member of the Bakar ImmunoX Program, the Cardiovascular Research Institute, and the Institute for Human Genetics.

Research Interests:

Asthma affects ~300 million people and causes ~250,000 deaths annually. The long-term overall vision of our research program is that fundamental insights into the biology of the airway epithelium will allow us to better understand asthma and other airway diseases and provide a firm foundation for developing new approaches to prevention, cure, or treatment of these diseases.

The concept that the airway epithelium plays a central role in asthma pathogenesis represents a relatively recent paradigm shift. We showed that direct effects of the type 2 cytokine IL-13 on resident airway cells were sufficient to induce airway hyperreactivity (AHR) and mucus overproduction. Our most important early contribution was the demonstration that IL-13-driven activation of the transcription factor (TF) STAT6 in airway epithelial cells causes AHR and mucus overproduction in mice. More recently, our studies of primary human bronchial epithelial (HBE) cells showed that IL-13 induces changes in expression, organization, and function of airway mucus glycoproteins (MUC5AC and MUC5B mucins). These changes lead to attachment (tethering) of mucus to the epithelium, prevent normal mucus clearance, and promote formation of obstructive mucus plugs that are a prominent feature of fatal asthma.

Completed and ongoing studies in the lab are intended to help reach a deeper understanding of the molecular mechanisms underlying airway epithelial dysfunction in asthma. We study the mechanisms of gene regulation in the airway epithelium and determine the contributions of specific gene expression changes to changes in airway epithelial function. We use a variety of approaches from cell and molecular biology, genomics, and computational biology. We have adapted powerful new methods, including single cell RNA-seq (scRNA-seq), ChIP-seq, and CRISPR, for use with HBE cells as well as with cells obtained directly from individuals with asthma. We collaborate extensively with experts in asthma clinical studies, genetics and genomics, and computational biology.

Publications: 

Steps Toward Cell Therapy for Cystic Fibrosis.

American journal of respiratory cell and molecular biology

Koh KD, Erle DJ

Whole Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.

American journal of respiratory and critical care medicine

Lee EY, Mak AC, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana J, Seibold MA, Burchard EG

Efficient RNP-Directed Human Gene Targeting Reveals SPDEF is Required for IL-13-Induced Mucostasis.

American journal of respiratory cell and molecular biology

Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ

Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms.

Cell reports

Godoy PM, Barczak AJ, DeHoff P, Srinivasan S, Etheridge A, Galas D, Das S, Erle DJ, Laurent LC

The airway epithelium in asthma.

Advances in immunology

Bonser LR, Erle DJ

The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.

The Journal of experimental medicine

Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR

A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.

Genome research

Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM

Singling out Th2 cells in eosinophilic esophagitis.

The Journal of clinical investigation

Eckalbar WL, Erle DJ

Putting Mucins on the Map.

American journal of respiratory and critical care medicine

Bonser LR, Erle DJ

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

The Journal of clinical investigation

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG

Large Differences in Small RNA Composition Between Human Biofluids.

Cell reports

Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ

Integrative approach identifies corticosteroid response variant in diverse populations with asthma.

The Journal of allergy and clinical immunology

Levin AM, Gui H, Hernandez-Pacheco N, Yang M, Xiao S, Yang JJ, Hochstadt S, Barczak AJ, Eckalbar WL, Rynkowski D, Samedy LA, Kwok PY, Pino-Yanes M, Erle DJ, Lanfear DE, Burchard EG, Williams LK

Tissue signals imprint ILC2 identity with anticipatory function.

Nature immunology

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM

Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Nature biotechnology

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Nature

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.

Immunity

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Nature biotechnology

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

American journal of respiratory and critical care medicine

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG

CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Oh J, Wu N, Barczak AJ, Barbeau R, Erle DJ, Shin JS

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.

Journal of clinical medicine

Bonser LR, Erle DJ

CRISPR-Cas9-mediated functional dissection of 3'-UTRs.

Nucleic acids research

Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ

Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.

The European respiratory journal

Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Cell reports

Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP

Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.

Cell

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.

Mucosal immunology

Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, Di H, Zou Y, Zhang H, Zhao J, Xu Y, Erle DJ, Zhen G

A tissue checkpoint regulates type 2 immunity.

Nature immunology

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.

PloS one

Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.

The Journal of clinical investigation

Bonser LR, Zlock L, Finkbeiner W, Erle DJ

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

The European respiratory journal

Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE

Massively Parallel Identification of Regulatory Variants in Asthma.

Annals of the American Thoracic Society

Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ

MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production.

Immunity

Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.

American journal of respiratory cell and molecular biology

Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ

Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.

PloS one

Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT

Effect of Exercise Rate and Route of Inhalation on Sulfur-Dioxide-induced Bronchoconstriction in Asthmatic Subjects1–3.

Robert A. Bethel, David J. Erle, Johanna Epstein, Dean Sheppard, Jay A. Nadel, Homer A. Boushey

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

American journal of physiology. Lung cellular and molecular physiology

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

Cancer cell

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Cancer cell

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF

Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.

American journal of respiratory and critical care medicine

Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X, Bonser LR, Zhao J, Xu Y, Erle DJ, Zhen G

Erratum: Corrigendum: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

Nature immunology

Michael Waterfield, Imran S Khan, Jessica T Cortez, Una Fan, Todd Metzger, Alexandra Greer, Kayla Fasano, Marc Martinez-Llordella, Joshua L Pollack, David J Erle, Maureen Su, Mark S Anderson

IL-17 and "TH2-high" asthma: Adding fuel to the fire?

The Journal of allergy and clinical immunology

Bhakta NR, Erle DJ

Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease.

Science translational medicine

Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL

The cell biology of asthma.

The Journal of cell biology

Erle DJ, Sheppard D

Massively parallel functional annotation of 3' untranslated regions.

Nature biotechnology

Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

Nature immunology

Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS

Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa.

Genome medicine

McErlean P, Berdnikovs S, Favoreto S, Shen J, Biyasheva A, Barbeau R, Eisley C, Barczak A, Ward T, Schleimer RP, Erle DJ, Boushey HA, Avila PC

Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics.

Genomics, proteomics & bioinformatics

Reisdorph N, Stearman R, Kechris K, Phang TL, Reisdorph R, Prenni J, Erle DJ, Coldren C, Schey K, Nesvizhskii A, Geraci M

S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.

Cytokine

Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron

Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

The Journal of clinical investigation

Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL

Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS

Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-ß1.

Cardiovascular research

Rahmutula D, Marcus GM, Wilson EE, Ding CH, Xiao Y, Paquet AC, Barbeau R, Barczak AJ, Erle DJ, Olgin JE

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

The Journal of cell biology

Yelena Bronevetsky, Alejandro V. Villarino, Christopher J. Eisley, Rebecca Barbeau, Andrea J. Barczak, Gitta A. Heinz, Elisabeth Kremmer, Vigo Heissmeyer, Michael T. McManus, David J. Erle, Anjana Rao, K. Mark Ansel

T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

The Journal of experimental medicine

Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.

The Journal of allergy and clinical immunology

Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM

An integrated nano-scale approach to profile miRNAs in limited clinical samples.

American journal of clinical and experimental immunology

Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM

Airway epithelial miRNA expression is altered in asthma.

American journal of respiratory and critical care medicine

Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.

BMC medical genomics

Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE

AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.

American journal of respiratory cell and molecular biology

Schroeder BW, Verhaeghe C, Park SW, Nguyenvu LT, Huang X, Zhen G, Erle DJ

The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

The Journal of clinical investigation

Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

Proceedings of the National Academy of Sciences of the United States of America

Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM

Toward a systematic understanding of mRNA 3' untranslated regions.

Proceedings of the American Thoracic Society

Zhao W, Blagev D, Pollack JL, Erle DJ

An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors.

PloS one

Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS

Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

The Journal of allergy and clinical immunology

Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F

Systemically dispersed innate IL-13-expressing cells in type 2 immunity.

Proceedings of the National Academy of Sciences of the United States of America

Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM

Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.

American journal of physiology. Lung cellular and molecular physiology

Gu N, Kang G, Jin C, Xu Y, Zhang Z, Erle DJ, Zhen G

Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking.

PloS one

Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

American journal of respiratory and critical care medicine

Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ

Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

Journal of immunology (Baltimore, Md. : 1950)

Klinger M, Kim JK, Chmura SA, Barczak A, Erle DJ, Killeen N

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.

Proceedings of the National Academy of Sciences of the United States of America

Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ

CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD

The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model.

Journal of immunology (Baltimore, Md. : 1950)

Nakagami Y, Favoreto S, Zhen G, Park SW, Nguyenvu LT, Kuperman DA, Dolganov GM, Huang X, Boushey HA, Avila PC, Erle DJ

Disease-specific gene expression profiling in multiple models of lung disease.

American journal of respiratory and critical care medicine

Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.

The Journal of clinical investigation

Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.

Proceedings of the National Academy of Sciences of the United States of America

Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

American journal of respiratory cell and molecular biology

Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG

Progress toward a systems biology approach to acute lung injury.

American journal of physiology. Lung cellular and molecular physiology

Frank JA, Erle DJ

Genomics and proteomics of lung disease: conference summary.

American journal of physiology. Lung cellular and molecular physiology

Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA

Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals.

Journal of immunology (Baltimore, Md. : 1950)

Chang WL, Coro ES, Rau FC, Xiao Y, Erle DJ, Baumgarth N

Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice.

PLoS pathogens

Horsnell WG, Cutler AJ, Hoving JC, Hoving CJ, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F

IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production.

American journal of respiratory cell and molecular biology

Zhen G, Park SW, Nguyenvu LT, Rodriguez MW, Barbeau R, Paquet AC, Erle DJ

The asthma channel? Stay tuned . . .

American journal of respiratory and critical care medicine

Erle DJ, Zhen G

A distinctive alveolar macrophage activation state induced by cigarette smoking.

American journal of respiratory and critical care medicine

Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ

IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production.

Journal of immunology (Baltimore, Md. : 1950)

Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ

Dissecting asthma using focused transgenic modeling and functional genomics.

The Journal of allergy and clinical immunology

Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ

Increased DNA microarray hybridization specificity using sscDNA targets.

BMC genomics

Barker CS, Griffin C, Dolganov GM, Hanspers K, Yang JY, Erle DJ

Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.

Respiratory research

Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ

Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells.

BMC immunology

Rodriguez MW, Paquet AC, Yang YH, Erle DJ

Abnormal alveolar development associated with elevated adenine nucleosides.

American journal of respiratory cell and molecular biology

Banerjee SK, Young HW, Barczak A, Erle DJ, Blackburn MR

Spotted long oligonucleotide arrays for human gene expression analysis.

Genome research

Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Nature medicine

Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ

Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells.

Developmental immunology

Shu F, Holzmann B, Seibold F, Erle D, Kearney JF

The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells.

American journal of respiratory cell and molecular biology

Venkayya R, Lam M, Willkom M, Grünig G, Corry DB, Erle DJ

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

American journal of respiratory cell and molecular biology

Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D

Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets.

The European respiratory journal

Solomon C, Christian DL, Chen LL, Welch BS, Kleinman MT, Dunham E, Erle DJ, Balmes JR

Intraepithelial lymphocytes in the lung: a neglected lymphocyte population.

American journal of respiratory cell and molecular biology

Erle DJ, Pabst R

Recent advances in molecular biological techniques and their relevance to pulmonary research.

Thorax

Robinson BW, Erle DJ, Jones DA, Shapiro S, Metzger WJ, Albelda SM, Parks WC, Boylan A

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.

The Journal of biological chemistry

Pfaff M, Liu S, Erle DJ, Ginsberg MH

Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization.

The Journal of cell biology

Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ

Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1.

Journal of immunology (Baltimore, Md. : 1950)

Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ

Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph.

Journal of immunology (Baltimore, Md. : 1950)

Abitorabi MA, Mackay CR, Jerome EH, Osorio O, Butcher EC, Erle DJ

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

The Journal of cell biology

Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

The Journal of experimental medicine

Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M

Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression.

American journal of respiratory cell and molecular biology

Erle DJ, Brown T, Christian D, Aris R

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

Journal of immunology (Baltimore, Md. : 1950)

Schweighoffer T, Tanaka Y, Tidswell M, Erle DJ, Horgan KJ, Luce GE, Lazarovits AI, Buck D, Shaw S

How do integrins integrate? The role of cell adhesion receptors in differentiation and development.

American journal of respiratory cell and molecular biology

Erle DJ, Pytela R

Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering.

The Journal of cell biology

Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ

Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.

American journal of respiratory cell and molecular biology

Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.

The Journal of biological chemistry

Erle DJ, Rüegg C, Sheppard D, Pytela R

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

The Journal of biological chemistry

Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R

Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.

The American review of respiratory disease

Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA